Déficits neuropsicológicos em crianças com apneia do sono: uma revisão de literatura

Alice de Souza Ramos; Ana Elisa Ribeiro Fernandes; Luciana Mendonça Alves

doi:10.51207/2179-4057.20240032

Authors

Alice de Souza Ramos Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brasil
Ana Elisa Ribeiro Fernandes Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brasil
Luciana Mendonça Alves Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brasil

DOI:

https://doi.org/10.51207/2179-4057.20240032

Keywords:

Sleep Apnea, Obstructive, Neuropsychology, Diagnosis, Child

Abstract

This study aimed to conduct a bibliographical review on neuropsychological deficits in children with sleep apnea. An integrative review on theoretical literature was used to achieve the purpose, analyzing, thereby, specific literature from the last ten years describing neuropsychological aspects of children with sleep apnea. Database consulted were: LILACS and other databases through Portal Regio-nal da Biblioteca Virtual de Saúde, MEDLINE through PubMed”, “Portal CAPES”, “PEDro” and “OTseeker”. The sample has 21 selected articles, selected from a population of 219 articles found on the databases. Randomized clinical trials, bibliographical reviews, cross- sectional and cohort studies were included. Both Redundant publications or articles that did not specify for age or focused on comorbi-dities were not considered. Most of the surveys evidenced the existence of neuropsychological changes related to sleep disturbance, which could cause difficulties at paying attention. Memorization and visual motor, speech and executive functions were compromised. Pathogenesis of comorbidities related to obstructive sleep apnea are caused by hypoxemia and sleep interruptions. Surgery is the main medical intervention mentioned in the literature, since there was no other research so far exploring other possi-bilities to solve these neuropsychological deficits. Articles indicate that sleep apnea can cause neuropsychological deficits on attention, memory, and executive functions. In addition, these articles suggests that this situation could be softened with proper treatment, although prognosis and diagnosis data need further evidence.

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Author Biographies

Alice de Souza Ramos, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brasil

Mestra em Ciências Fonoaudiológicas.

Ana Elisa Ribeiro Fernandes, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brasil

Mestra em Ciências da Saúde da Criança e do Adolescente.

Luciana Mendonça Alves, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brasil

Doutora em Linguística.

References

American Academy of Sleep Medicine. (2014). International Classification of Sleep Disorders (3rd ed.). AASM.

Barros, E. L., Pradella-Hallinan, M., Moreira, G. A., Stefanini, D. O. S., Tufik, S., & Fujita, R. R. (2014). Acompanhamento clínico de crianças com distúrbios respiratórios do sono. Brazilian Journal of Otorhinolaryngology, 80(4), 277-284. https://doi.org/10.1016/j.bjorl.2014.05.008

Cardoso, T. S. G., Pompéia, S., & Miranda, M. C. (2018). Cognitive and behavioral effects of obstructive sleep apnea syndrome in children: a systematic literature review. Sleep Medicine, 46, 46-55. https://doi.org/10.1016/j.sleep.2017.12.020

Chervin, R. D., Ruzicka, D. L., Hoban, T. F., Fetterolf, J. L., Garetz, S. L., Guire, K. E., Dillon, J. E., Felt, B. T., Hodges, E. K., & Giordani, B. J. (2012). Esophageal pressures, polysomnography, and neurobehavioral outcomes of adenotonsillectomy in children. Chest, 142(1), 101-110. https://doi.org/10.1378/chest.11-2456

Chervin, R. D., Garetz, S. L., Ruzicka, D. L., Hodges, E. K., Giordani, B. J., Dillon, J. E., Felt, B. T., Hoban, T. F., Guire, K. E., O’Brien, L. M., & Burns, J. W. (2014). Do respiratory cycle-related EEG changes or arousals from sleep predict neurobehavioral deficits and response to adenotonsillectomy in children? Journal of Clinical Sleep Medicine, 10(8), 903-911. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4106946/

Chervin, R. D., Ellenberg, S. S., Hou, X., Marcus, C. L., Garetz, S. L., Katz, E. S., Hodges, E. K., Mitchell, R. B., Jones, D. T., Arens, R., Amin, R., Redline, S., & Rosen, C. L. (2015). Prognosis for spontaneous resolution of OSA in children. Chest, 148(5), 1204-1213. https://doi.org/10.1378/chest.14-2873

Chung, S., Hodges, E. K., Ruzicka, D. L., Hoban, T. F., Garetz, S. L., Guire, K. E., Felt, B. T., Dillon, J. E., Chervin, R. D., & Giordani, B. (2016). Improved behavior after adenotonsillectomy in children with higher and lower IQ. International Journal of Pediatric Otorhinolaryngology, 80, 21-25. https://doi.org/10.1016/j.ijporl.2015.11.005

Corrêa, C. C., Cavalheiro, M. G., Maximino, L. P., & Weber, S. A. T. (2017). Obstructive sleep apnea and oral language disorders. Brazilian Journal of Otorhinolaryngology, 83(1), 98-104. https://doi.org/10.1016/j.bjorlp.2016.12.003

Csábi, E., Benedek, P., Janacsek, K., Katona, G., & Nemeth, D. (2013). Sleep disorder in childhood impairs declarative but not nondeclarative forms of learning. Journal of Clinical and Experimental Neuropsychology, 35(7), 677-685. https://doi.org/10.1080/13803395.2013.815693

Csábi, E., Benedek, P., Janacsek, K., Zavecz, Z., Katona, G., & Nemeth, D. (2016). Declarative and non-declarative memory consolidation in children with sleep disorder. Frontiers in Human Neuroscience, 9, 709. https://doi.org/10.3389/fnhum.2015.00709

Danielsen, Y. S., Skjåkødegård, H. F., Bjorvatn, B., Juliusson, P. B., & Pallesen, S. (2021). Polysomnographic comparison of sleep-in children with obesity and normal weight without suspected sleep-related breathing disorder. Clinical Obesity, 12(1), e12493. https://doi.org/10.1111/cob.12493

Esteller, E. (2015). Síndrome de la apnea-hipoapnea obstructiva del sueño en el niño: más allá de la hipertrofia adenoamigdalar. Acta Otorrinolaringológica Española, 66(2), 111-119. https://doi.org/10.1016/j.otorri.2014.05.001

Hagström, K., Saarenpää-Heikkilä, O., Himanen, S. L., Lampinlampi, A. M., & Rantanen, K. (2020). Neurobehavioral outcomes in school-aged children with primary snoring. Archives of Clinical Neuropsychology, 35(4), 401-412. https://doi.org/10.1093/arclin/acz053

Hodges, E., Marcus, C. L., Kim, J. Y., Xanthopoulos, M., Shults, J., Giordani, B., Beebe, D. W., Rosen, C. L., Chervin, R. D., Mitchell, R. B., Katz, E. S., Gozal, D., Redline, S., Elden, L., Arens, R., Moore, R., Taylor, H. G., Radcliffe, J., & Thomas, N. H. (2018). Depressive symptomatology in school-aged children with obstructive sleep apnea syndrome: incidence, demographic factors, and changes following a randomized controlled trial of adenotonsillectomy. Sleep, 41(12), zsy180. https://doi.org/10.1093/sleep/zsy180

Kocuta, M. (2017). Apnea en niños: diagnóstico y tratamiento. Revista del Ateneo Argentino de Odontología, 57(2), 19-25. https://www.ateneo-odontologia.org.ar/articulos/lvii02/articulo2.pdf

Li-Ang, L., & Hai-Hua, C. (2021). Brain tissue integrity and autonomic function alterations in childhood OSA and ADHD, and after adenotonsillectomy. National Library of Medicine. https://clinicaltrials.gov/ct2/show/NCT04732572

Marcus, C. L., Moore, R. H., Rosen, C. L., Giordani, B., Garetz, S. L., Taylor, H. G., Mitchell, R. B., Amin, R., Katz, E. S., Arens, R., Paruthi, S., Muzumdar, H., Gozal, D., Thomas, N. H., Ware, J., Beebe, D., Snyder, K., Elden, L., Sprecher, R. C., Willging, P., … Childhood Adenotonsillectomy Trial (CHAT) (2013). A randomized trial of adenotonsillectomy for childhood sleep apnea. The New England Journal of Medicine, 368(25), 2366-2376. https://doi.org/10.1056/NEJMoa1215881

Menzies, B., Teng, A., Burns, M., & Lah, S. (2022). Neurocognitive outcomes of children with sleep disordered breathing: A systematic review with meta-analysis. Sleep Medicine Reviews, 63, 101629. https://doi.org/10.1016/j.smrv.2022.101629

Mesa, T., & Riffo, C. (2017). Alteraciones cognitivas y conductuales en los transtornos respiratorios del sueño (TRS) en niños. Neumología Pediátrica, 12(2), 66-70. https://doi.org/10.51451/np.v12i2.271

Neves, G. S. M. L., Macedo, P., & Gomes, M. M. (2017). Transtornos do sono: atualização (1/2). Revista Brasileira de Neurologia, 53(3), 19-30. https://docs.bvsalud.org/biblioref/2017/12/876873/rbn-533-3-transtornos-do-sono-1-2.pdf

Oliveira, B., & Martino, M. M. F. (2013). Análise das funções cognitivas e sono na equipe de enfermagem nos turnos diurno e noturno. Revista Gaúcha de Enfermagem, 34(1), 30-36. https://doi.org/10.1590/S1983-14472013000100004

Rama, A. N., & Zachariah, R. (2023). Normal human sleep. In C. A. Kushida (Ed.), Encyclopedia of Sleep and Circadian Rhythm (pp. 21-30). https://www.sciencedirect.com/science/article/pii/B9780128229637001651

Schneider, H. E., Lam, J. C., & Mahone, E. M. (2016). Sleep disturbance and neuropsychological function in young children with ADHD. Child Neuropsychology, 22(4), 493-506. https://doi.org/10.1080/09297049.2015.1018153

Silva, P. M. J., Feitoza, C. C., Franco-Micheloni, A. L., & Pizzol, K. D. C. (2021). Síndrome da apneia e hipopneia obstrutiva do sono na infância: aspectos odontológicos. Revista Brasileira Multidisciplinar, 24(1), 187-198. https://doi.org/10.25061/2527-2675/ReBraM/2021.v24i1.723

Skjåkødegård, H. F., Danielsen, Y. S., Frisk, B., Hystad, S. W., Roelants, M., Pallesen, S., Conlon, R. P. K., Wilfley, D. E., & Juliusson, P. B. (2021). Beyond sleep duration: Sleep timing as a risk factor for childhood obesity. Pediatric Obesity, 16(1), e12698. https://doi.org/10.1111/ijpo.12698

Smith, F. R. H., Gaskell, M. G., Weighall, A. R., Warmington, M., Reid, A. M., & Henderson, L. M. (2018). Consolidation of vocabulary is associated with sleep in typically developing children, but not in children with dyslexia. Developmental Science, 21(5), e12639. https://doi.org/10.1111/desc.12639

Tapia, I. E., Kim, J., Radcliffe, J., Younes, M., & Marcus, C. L. (2018). Relationship between neurobehavioral function and sleep depth in children with obstructive sleep apnea. Sleep, 41(Suppl 1), A278. https://doi.org/10.1093/sleep/zsy061.747

Taylor, H. G., Bowen, S. R., Beebe, D. W., Hodges, E., Amin, R., Arens, R., Chervin, R. D., Garetz, S. L., Katz, E. S., Moore, R. H., Morales, K. H., Muzumdar, H., Paruthi, S., Rosen, C. L., Sadhwani, A., Thomas, N. H., Ware, J., Marcus, C. L., Ellenberg, S. S., ... Giordani, B. (2016). Cognitive effects of adenotonsillectomy for obstructive sleep apnea. Pediatrics, 138(2), e20154458. https://doi.org/10.1542/peds.2015-4458

Yin, G. P., Ye, J. Y., Xu, J. K., Cao, X., Zhao, C. M., & Zhang, Y. H. (2019). Analysis of polysomnography results between pre- and post-operation in pediatric obstructive sleep apnea hypopnea syndrome patients. Chinese Journal of Otorhinolaryngology Head and Neck Surgery, 54(5), 367-372. https://doi.org/10.3760/cma.j.issn.1673-0860.2019.05.010.